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2012

Pereira, Alban R.; Kale, Andrew J.; Fenley, Andrew T.; Byrum, Tara; Debonsi, Hosana M.; Gilson, Michael K.; Valeriote, Frederick A.; Moore, Bradley S.; Gerwick, William H. "The Carmaphycins: New Proteasome Inhibitors Exhibiting an α,β-Epoxyketone Warhead from a Marine Cyanobacterium" ChemBioChem 2012, Ahead of Print.

Engene, N.; Rottacker, E.C.; Kasˆtovsky′, J.; Byrum, T.; Choi, H.; Ellisman, M.H.; Koma'rek, J.; Gerwick, W.H. "Moorea producta gen. nov., sp. nov. and Moorea bouillonii comb. nov., tropical marine cyanobacteria rich in bioactive secondary metabolites" Int. J. Syst. Evol. Microbiol. 2012, in press.

Leao, Pedro N.; Engene, Niclas; Antunes, Agostinho; Gerwick, William H.; Vasconcelos, Vitor "The chemical ecology of cyanobacteria" Natural Product Reports 2012, 29, 372-391.

Gerwick, William H.; Moore, Bradley S. "Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology." Chemistry & Biology 2012, 19, 85-98.

Martinez-Luis, Sergio; Cherigo, Lilia; Arnold, Elizabeth; Spadafora, Carmenza; Gerwick, William H.; Cubilla-Rios, Luis "Antiparasitic and anticancer constituents of the endophytic fungus Aspergillus sp. strain F1544" Natural Product Communications 2012, 7, 165-168.

Malloy, Karla L.; Suyama, Takashi L.; Engene, Niclas; Debonsi, Hosana; Cao, Zhengyu; Matainaho, Teatulohi; Spadafora, Carmenza; Murray, Thomas F.; Gerwick, William H. "Credneramides A and B: Neuromodulatory Phenethylamine and Isopentylamine Derivatives of a Vinyl Chloride-Containing Fatty Acid from cf. Trichodesmium sp. nov." Journal of Natural Products 2012, 75, 60-66.

Choi, Hyukjae; Proteau, Philip J.; Byrum, Tara; Gerwick, William H. "Cymatherelactone and cymatherols A-C, polycyclic oxylipins from the marine brown alga Cymathere triplicate" Phytochemistry 2012, 73, 134-141.

Malloy, Karla L.; Choi, Hyukjae; Fiorilla, Catherine; Valeriote, Fred A.; Matainaho, Teatulohi; Gerwick, William H. "Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interaction" Bioorganic & Medicinal Chemistry Letters 2012, 22, 683-688.

Gehret, Jennifer J.; Gu, Liangcai; Geders, Todd W.; Brown, William Clay; Gerwick, Lena; Gerwick, William H.; Sherman, David H.; Smith, Janet L. "Structure and activity of DmmA, a marine haloalkane dehalogenase" Protein Science 2012, 21, 239-248.

Molinar, Eunice; Rios, Nivia; Spadafora, Carmenza; Elizabeth Arnold, A.; Coley, Phyllis D.; Kursar, Thomas A.; Gerwick, William H.; Cubilla-Rios, Luis "Coibanoles, a new class of meroterpenoids produced by Pycnoporus sanguineus" Tetrahedron Letters 2012, 53, 919-922.

Varughese, Titto; Rios, Nivia; Higginbotham, Sarah; Elizabeth Arnold, A.; Coley, Phyllis D.; Kursar, Thomas A.; Gerwick, William H.; Rios, Luis Cubilla "Antifungal depsidone metabolites from Cordyceps dipterigena, an endophytic fungus antagonistic to the phytopathogen Gibberella fujikuroi" Tetrahedron Letters 2012, 53, 1624-1626.


2011

Jones, Adam C.; Monroe, Emily A.; Gerwick, William H. "Elegant Metabolite Biosynthesis" Chemistry & Biology 2011, 18, 281-283.

Karla L. Malloy, Francisco A. Villa, Niclas Engene, Teatulohi Matainaho, Lena G. Gerwick and William H. Gerwick. "Malyngamide 2, an Oxidized Lipopeptide with Nitric Oxide Inhibiting Activity from a Papua New Guinea Marine Cyanobacterium." J. Nat. Prod. 2011, 74, 95-98.

Eduardo Esquenazi, Adam C. Jones, Tara Byrum, Pieter C. Dorrestein and William H. Gerwick. "Temporal dynamics of natural product biosynthesis in marine cyanobacteria." Proc. Natl. Acad. Sci. 2011, 108, 5226-5231.

Rashel V. Grindberg, Thomas Ishoey, Dumitru Brinza, Eduardo Esquenazi, R. Cameron Coates, Wei-ting Liu, Lena Gerwick, Pieter C. Dorrestein, Pavel Pevzner, Roger Lasken, William H. Gerwick. "Single Cell Genome Amplification Accelerates Natural Product Pathway Characterization from Complex Microbial Assemblages" PLoS One 2011, 6, e18565.

Joshawna K. Nunnery, Takashi L. Suyama, and William H. Gerwick. "Expedient Synthesis of α,α-Dimethyl-β-Hydroxy Carbonyl Scaffolds via Evans' Aldol Reaction with a Tertiary Enolate" Tetrahedron Lett. 2011, 52, 2929-2932.

Jennifer J. Gehret, Liangcai Gu, William H. Gerwick, Peter Wipf, David H. Sherman, Janet L. Smith. "Structural Insights into Terminal Alkene Formation by the Thioesterase in the Curacin A Biosynthetic Pathway" J. Biol. Chem. 2011, 286, 14445-14454.

Bingnan Han, Uwe Reinscheid, William H. Gerwick, Harald Gross. "The structure elucidation of isomalyngamide K from the marine cyanobacterium Lyngbya majuscula by experimental and DFT computational methods." J. Molecular Structure 2011, 989, 109-113.

Eufemio Moreno, Titto Varughese, Carmenza Spadafora, A. Elizabeth Arnold, Phyllis D. Coley, Thomas A. Kursar, William H. Gerwick, Luis Cubilla-Rios "Chemical Constituents of the New Endophytic Fungus Mycosphaerella sp. nov. and Their Anti-parasitic Activity" Natural Product Communications 2011, 6, 835-840.

Liangcai Gu, Eli B. Eisman, Somnath Dutta, Titus M. Franzmann, Stefan Walter, William H. Gerwick, Georgios Skiniotis, and David H. Sherman. "Tandem Acyl Carrier Proteins in the Curacin Biosynthetic Pathway: Promotion of Consecutive Multienzyme Reactions with a Synergistic Effect" Angewandte Chemie, International Ed. 2011, 50, 2795-2798.

Carla S. Jones, Eduardo Esquenazi, Pieter C. Dorrestein, and William H. Gerwick. "Probing the in vivo biosynthesis of scytonemin, a cyanobacterial ultraviolet radiation sunscreen, through small scale stable isotope incubation studies and MALDI-TOF mass spectrometry." Bioorganic & Medicinal Chemistry 2011 (in press).

Alban R. Pereira, Lena Etzbach, Niclas Engene, Rolf Müller and William H. Gerwick, "Molluscicidal Metabolites from an Assemblage of Palmyra Atoll Cyanobacteria", J. Nat. Prod. 2011, 74, 1175-1181.

Mevers, Emily; Liu, Wei-Ting; Engene, Niclas; Mohimani, Hosein; Byrum, Tara; Pevzner, Pavel A.; Dorrestein, Pieter C.; Spadafora, Carmenza; Gerwick, William H. "Cytotoxic Veraguamides, Alkynyl Bromide Containing Cyclic Depsipeptides from the Marine Cyanobacterium cf. Oscillatoria margaritifera" J. Nat. Prod. 2011, 74, 928-936.

Udwary, Daniel W.; Gontang, Erin A.; Jones, Adam C.; Jones, Carla S.; Schultz, Andrew W.; Winter, Jaclyn M.; Yang, Jane Y.; Beauchemin, Nicholas; Capson, Todd L.; Clark, Benjamin R.; Esquenazi, Eduardo; Eustaquio, Alessandra S.; Freel, Kelle; Gerwick, Lena; Gerwick, William H.; Gonzalez, David; Liu, Wei-Ting; Malloy, Karla L.; Maloney, Katherine N.; Nett, Markus; Nunnery, Joshawna K.; Penn, Kevin; Prieto-Davo, Alejandra; Simmons, Thomas L.; Weitz, Sara; Wilson, Michael C.; Tisa, Louis S.; Dorrestein, Pieter C.; Moore, Bradley S. "Significant natural product biosynthetic potential of actinorhizal symbionts of the genus Frankia, as revealed by comparative genomic and proteomic analyses." Applied and Environmental Microbiology 2011, 77, 3617-3625.

Jones, Adam C.; Monroe, Emily A.; Podell, Sheila; Hess, Wolfgang R.; Klages, Sven; Esquenazi, Eduardo; Niessen, Sherry; Hoover, Heather; Rothmann, Michael; Lasken, Roger S.; Yates, John R., III; Reinhardt, Richard; Kube, Michael; Burkart, Michael D.; Allen, Eric E.; Dorrestein, Pieter C.; Gerwick, William H.; Gerwick, Lena "Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula" Proceedings of the National Academy of Sciences of the United States of America 2011, 108, 8815-8820.

Engene, Niclas; Choi, Hyukjae; Esquenazi, Eduardo; Rottacker, Erin C.; Ellisman, Mark H.; Dorrestein, Pieter C.; Gerwick, William H. "Underestimated biodiversity as a major explanation for the perceived rich secondary metabolite capacity of the cyanobacterial genus Lyngbya" Environmental Microbiology 2011, 13, 1601-1610.

Engene, Niclas; Choi, Hyukjae; Esquenazi, Eduardo; Byrum, Tara; Villa, Francisco A.; Cao, Zhengyu; Murray, Thomas F.; Dorrestein, Pieter C.; Gerwick, Lena; Gerwick, William H. "Phylogeny-guided isolation of ethyl tumonoate A from the marine cyanobacterium cf. Oscillatoria margaritifera." Journal of Natural Products 2011, 74, 1737-1743.

Gutierrez, Marcelino; Pereira, Alban R.; Debonsi, Hosana M.; Ligresti, Alessia; Di Marzo, Vincenzo; Gerwick, William H. "Cannabinomimetic Lipid from a Marine Cyanobacterium." Journal of Natural Products 2011, 74, 2313-2317.


2010

Adam C. Jones, Emily A. Monroe, Eli Eisman, Lena Gerwick, David H. Sherman, and William H. Gerwick, "The Unique Mechanistic Transformations Involved in the Biosynthesis of Modular Natural Products from Marine Cyanobacteria," Nat. Prod. Rep, 2010, 27, 1048 - 1065.

Nunnery, Joshawna K.; Mevers, Emily; Gerwick, William H. "Biologically active secondary metabolites from marine cyanobacteria." Current Opinion in Biotechnology 2010, 21, 787-793.

S.V. Jabba, A. Prakash, S. M. Dravid, W. H. Gerwick and T. F. Murray "Antillatoxin, a Novel Lipopeptide, Enhances Neurite Outgrowth in Immature Cerebrocortical Neurons Through Activation of Voltage Gated Sodium Channels" Journal of Pharmacology and Experimental Therapeutics 2010, 332, 698-709.

Niclas Engene, R. Cameron Coates and William H. Gerwick, "16S rRNA Gene Heterogeneity in the Filamentous Marine Cyanobacterial Genus Lyngbya" J. Phycology 2010, 46, 591-601.

Marcy J. Balunas, Roger G. Linington, Kevin Tidgewell, Amanda M. Fenner, Luis-David Ureña, Gina Della Togna, Dennis E. Kyle, and William H. Gerwick "Dragonamide E, a Modified Linear Lipopeptide from Lyngbya majuscula with Antileishmanial Activity", J. Natural Products, 2010, 73, 60-66. PMCID: PMC2834186

Suyama, Takashi L.; Cao, Zhengyu; Murray, Thomas F.; Gerwick, William H. "Ichthyotoxic brominated diphenyl ethers from a mixed assemblage of a red alga and cyanobacterium: Structure clarification and biological properties." Toxicon 2010, 55, 204-210.

Alban R. Pereira, Tara Byrum, Grant M. Shibuya, Christopher D. Vanderwal, and William H. Gerwick. "Structure Revision and Absolute Configuration of Malhamensilipin A from the Freshwater Chrysophyte Poterioochromonas malhamensis" J. Natural Products 2010, 73, 279-283.

Alban R. Pereira, Christine McCue, and William H. Gerwick. "Cyanolide A, a Glycosidic Macrolide with Potent Molluscicidal Activity from the Papua New Guinea Cyanobacterium Lyngbya bouillonii" J. Natural Products 2010, 73, 217-220. PMCID: PMC2834176

Bedke, D.; Shibuya, G.; Pereira, A.; Gerwick, W.; Vanderwal, C. "A Concise Enantioselective Synthesis of the Chlorosulfolipid Malhamensilipin A," J. Am. Chem. Soc. 2010, 132, 2542-2543.

Choi, H.; Engene, N.; Smith, J.E.; Preskitt, L.B.; Gerwick, W.H. "Crossbyanols A-D, Toxic Brominated Polyphenyl Ethers from the Hawai'ian Bloom-forming Cyanobacterium Leptolyngbya crossbyana" J. Natural Products 2010, 73, 517-522. PMCID: PMC2859106

Gutiérrez, M; Tidgewell, K.; Capson, T.L.; Engene, N.; Almanza, A.; Schemies, J.; Jung, M.; Gerwick, W.H. "Malyngolide Dimer, a Bioactive Symmetric Cyclodepside from the Panamanian Marine Cyanobacterium Lyngbya majuscula" J. Natural Products 2010, 73, 709-711.

Kevin Tidgewell, Niclas Engene, Tara Byrum, Joseph Media, Fred A. Valeriote, William H. Gerwick. "Diversification of a Modular Natural Product Pathway: Production of Apratoxins F and G, Two Cytotoxic Cyclic Depsipeptides from a Palmyra Collection of Lyngbya bouillonii," ChemBioChem 2010, 11, 1458-1466.

Sanchez, Laura M.; Lopez, Dioxelis; Vesely, Brian A.; Della Togna, Gina; Gerwick, William H.; Kyle, Dennis E.; Linington, Roger G. Almiramides A-C: Discovery and Development of a New Class of Leishmaniasis Lead Compounds. Journal of Medicinal Chemistry 2010, 53, 4187-4197.

Leão, P.N.; Pereira, A.R.; Liuc, W.T.; Ngd, J.; Pevznere, P.A.; Dorrestein, P.C.; König, G.M.; Vasconcelosa, M.T.S.D.; Vasconcelosa, V.M.; Gerwick, W.H. Synergistic allelochemicals from a freshwater cyanobacterium. Proc. Natl. Acad. Sci. 2010, 107, 11183-8.

Gross, H.; McPhail, K.L.; Goeger, D.E.; Valeriote, F.A.; Gerwick, W.H. "Two Cytotoxic Stereoisomers of Malyngamide C, 8-Epi-Malyngamide C and 8-O-Acetyl-8-epi-Malyngamide C, from the Marine Cyanobacterium Lyngbya majuscula", Phytochemistry 2010, 71, 1729-1735.

Dheeraj Khare, Bo Wang, Liangcai Gu, Jamie Razelun, David H. Sherman, William H. Gerwick, Kristina Håkansson, and Janet L. Smith. "Conformational switch triggered by α-ketoglutaration by a halogenase of curacin A biosynthesis" Proc. Natl. Acad. Sci. 2010 doi:10.1073/pnas.1006738107.

Hyukjae Choi, Alban R. Pereira, Zhengyu Cao, Cynthia F. Shuman, Niclas Engene, Tara Byrum, Teatulohi Matainaho, Thomas F. Murray, Alfonso Mangoni and William H. Gerwick. "The Hoiamides, Structurally-Intriguing Neurotoxic Lipopeptides from Papua New Guinea Marine Cyanobacteria." J. Nat. Prod. 2010, 73, 1411-1421.

Alban R. Pereira, Zhengyu Cao, Niclas Engene, Irma E. Soria-Mercado, Thomas F. Murray, and William H. Gerwick. "Palmyrolide A, an Unusually Stabilized Neuroactive Macrolide from Palmyra Atoll Cyanobacteria." Organic Letters 2010, 12, 4490-4493.

Zhengyu Cao, William H. Gerwick, Thomas F. Murray. "Antillatoxin Is a Voltage-Gated Sodium Channel Activator That Displays Unique Efficacy in Heterologously Expressed rNav1.2, rNav1.4 and rNav1.5 Alpha Subunits." BMC Neuroscience 2010, 11, 154.


2009

Linington, Roger G.; Clark, Benjamin R.; Trimble, Erin E.; Almanza, Alejandro; Urena, Luis-David; Kyle, Dennis E.; Gerwick, William H. "Antimalarial peptides from marine cyanobacteria: Isolation and structural elucidation of gallinamide A." J. Nat. Prod. 2009, 72, 14-17.

Gu, L., Wang, B., Kulkarni, A, Geders, T. W., Grindberg, R. V., Gerwick, L., Håkansson, K., Wipf, P., Smith, J. L., Gerwick, W. H. and Sherman, D. H. "Metamorphic enzyme assembly in polyketide diversification." Nature 2009, 459, 731-735.

Gutiérrez, M.; Andrianasolo, E. H.; Shin, W. K.; Goeger, D. E.; Yokochi, A.; Schemies, J.; Jung, M.; France, D.; Cornell-Kennon, S.; Lee, E.; Gerwick, W. H. "Structural and Synthetic Investigations of Tanikolide Dimer, a SIRT2 Selective Inhibitor, and Tanikolide Seco Acid from the Madagascar Marine Cyanobacterium Lyngbya majuscula" J. Org. Chem. 2009, 74, 5267-5275.

Sorrels, Carla M.; Proteau, Philip J.; Gerwick, William H.. Organization, evolution, and expression analysis of the biosynthetic gene cluster for scytonemin, a cyanobacterial UV-absorbing pigment. Applied and Environmental Microbiology 2009, 75, 4861-4869.

Ng, Julio; Bandeira, Nuno; Liu, Wei-Ting; Ghassemian, Majid; Simmons, Thomas L.; Gerwick, William H.; Linington, Roger; Dorrestein, Pieter C.; Pevzner, Pavel A. Dereplication and de novo sequencing of nonribosomal peptides. Nature Methods 2009, 6, 596-599.

Simmons, T. Luke; Nogle, Lisa M.; Media, Joseph; Valeriote, Frederick A.; Mooberry, Susan L.; Gerwick, William H. Desmethoxymajusculamide C, a cyanobacterial depsipeptide with potent cytotoxicity in both cyclic and ring-opened forms. Journal of Natural Products 2009, 72, 1011-1016.

Esquenazi, Eduardo; Dorrestein, Pieter C.; Gerwick, William H.. Probing marine natural product defenses with DESI-imaging mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America 2009, 106, 7269-7270.

Bedke, D. Karl; Shibuya, Grant M.; Pereira, Alban; Gerwick, William H.; Haines, Thomas H.; Vanderwal, Christopher D. Relative Stereochemistry Determination and Synthesis of the Major Chlorosulfolipid from Ochromonas danica. Journal of the American Chemical Society 2009, 131, 7570-7572.

Liu, Wei-Ting; Ng, Julio; Meluzzi, Dario; Bandeira, Nuno; Gutierrez, Marcelino; Simmons, Thomas L.; Schultz, Andrew W.; Linington, Roger G.; Moore, Bradley S.; Gerwick, William H.; Pevzner, Pavel A.; Dorrestein, Pieter C. Interpretation of Tandem Mass Spectra Obtained from Cyclic Nonribosomal Peptides. Analytical Chemistry (Washington, DC, United States) 2009, 81, 4200-4209.

Pereira, Alban; Cao, Zhengyu; Murray, Thomas F.; Gerwick, William H. Hoiamide A, a Sodium Channel Activator of Unusual Architecture from a Consortium of Two Papua New Guinea Cyanobacteria. Chemistry & Biology 2009, 16, 893-906.

Soria-Mercado, Irma E.; Pereira, Alban; Cao, Zhengyu; Murray, Thomas F.; Gerwick, William H. Alotamide A, a Novel Neuropharmacological Agent from the Marine Cyanobacterium Lyngbya bouillonii. Organic Letters 2009, 11, 4704-4707.

Gu, L.; Wang, B.; Kulkarni, A.; Gehret, J. J.; Lloyd, K. R.; Gerwick, L.; Gerwick, W. H.; Wipf, P.; Hakansson, K.; Smith, J. L.; Sherman, D. H. "Polyketide Decarboxylative Chain Termination Preceded by O-Sulfonation in Curacin A Biosynthesis." J. Am. Chem. Soc. 2009, 131, 16033-16035.

Akey, D.L.; Razelun, J.R.; Tehranisa, J.; Sherman, D.H.; Gerwick, W.H.; Smith, J. L. "Crystal Structures of Dehydratase Domains from the Curacin Polyketide Biosynthetic Pathway", Structure, 2010, 18, 94-105.

Esquenazi, Eduardo; Yang, Yu-Liang; Watrous, Jeramie; Gerwick, William H.; Dorrestein, Pieter C. "Imaging mass spectrometry of natural products." Natural Product Reports 2009, 26, 1521-1534.

Martinez-Luis, Sergio; Cherigo, Lilia; Spadafora, Carmenza; Gerwick, William H.; Cubilla-Rios, Luis. Additional anti-leishmanial constituents of the panamanian endophytic fungus Edenia sp." Revista Latinoamericana de Quimica 2009, 37, 104-114.

Taniguchi, Masatoshi; Nunnery, Joshawna K.; Engene, Niclas; Esquenazi, Eduardo; Byrum, Tara; Dorrestein, Pieter C.; Gerwick, William H. "Palmyramide A, a Cyclic Depsipeptide from a Palmyra Atoll Collection of the Marine Cyanobacterium Lyngbya majuscula." Journal of Natural Products 2010, 73, 393-398.

Huynh, Minh U.; Elston, Matthew C.; Hernandez, Nick M.; Ball, David B.; Kajiyama, Shin-ichiro; Irie, Kazuhiro; Gerwick, William H.; Edwards, Daniel J. Enzymatic Production of (-)-Indolactam V by LtxB, a Cytochrome P450 Monooxygenase. Journal of Natural Products 2009, 73, 71-74

Jones, Adam C.; Gerwick, Lena; Gonzalez, David; Dorrestein, Pieter C.; Gerwick, William H.. Transcriptional analysis of the jamaicamide gene cluster from the marine cyanobacterium Lyngbya majuscula and identification of possible regulatory proteins. BMC Microbiology 2009, 9


2008

Wolf Wrasidlo, Ainhoa Mielgo, Vicente Torres, Simone Barbero, Konstantin Stolenov, Takashi Suyama, William Gerwick, Dennis Carson & Dwayne G. Stupack "The marine lipopeptide Somocystinamide A triggers apoptosis via caspase 8," Proceedings of the National Academy of Science, 2008, 105, 2313-2318.

T. Luke Simmons, R. Cameron Coates, Benjamin R. Clark, Niclas Engene, David Gonzalez, Eduardo Esquenazi, Pieter C. Dorrestein and William H. Gerwick. "Biosynthetic Origin of Natural Products Isolated from Marine Microorganism-Invertebrate Assemblages," Proceedings of the National Academy of Science, 2008, 105, 4587-4594.

David Gonzalez, Eduardo Esquenazi, William H. Gerwick and Pieter C. Dorrestein. "Visualizing the spatial distribution of secondary metabolites produced by marine cyanobacteria and sponges via MALDI-TOF imaging." Molecular BioSystems 2008, 4, 562-570.

Clark, B.R.; Engene, N.; Teasdale, M.E.; Rowley, D.C.; Matainaho, T.; Valeriote, F.A.; Gerwick, W.H. Natural Products Chemistry and Taxonomy of the Marine Cyanobacterium Blennothrix cantharidosmum. Journal of Natural Products 2008, 71, 1530-1537.

Gutierrez, Marcelino; Suyama, Takashi; Engene, Niclas; Wingerd, Joshua; Matainaho, Teatulohi; Gerwick, William H. "Apratoxin D, a Potent Cytotoxic Cyclodepsipeptide from Papua New Guinea Collections of the Marine Cyanobacteria Lyngbya majuscula and Lyngbya sordida". J. Nat. Prod. 2008, 71, 1099-1103.

Thomas L. Simmons, Niclas Engene, Luis David Ureña, Luz I. Romero, Eduardo Ortega-Barría, Lena Gerwick, and William H. Gerwick, "Viridamides A and B, Lipodepsipeptides with Anti-Protozoan Activity from the Marine Cyanobacterium Oscillatoria nigro-viridis" J. Nat. Prod. 2008, 71, 1544-1550.

Medina, Rebecca A.; Goeger, Douglas E.; Hills, Patrice; Mooberry, Susan L.; Huang, Nelson; Romero, Luz I.; Ortega-Barria, Eduardo; Gerwick, William H.; McPhail, Kerry L. "Coibamide A, a Potent Antiproliferative Cyclic Depsipeptide from the Panamanian Marine Cyanobacterium Leptolyngbya sp." Journal of the American Chemical Society 2008, 130, 6324-6325.

William Gerwick, Tara Byrum, Tristan Carland, R. Cameron Coates, Niclas Engene, Eduardo Esquenazi, Lena Gerwick, Rashel Grindberg, Mindy Johnson, Adam Jones, Karla Malloy, Joshawna Nunnery, Alban Pereira, Irma Soria, Carla Sorrels, Masatoshi Taniguchi, Kevin Tidgewell, Francisco Villa, Oliver Vining, Pieter Dorrestein, Liangcai Gu, and David H.Sherman. "Integrating Chemical and Biochemical Approaches to Natural Products Drug Discovery from Marine Cyanobacteria", Proceedings from the New Developments in Drug Discovery on Natural Products and Traditional Medicines" NIPER, India, November 2008, 33-43.

Suyama, T.L.; Gerwick, W.H. "Stereospecific Total Synthesis of Somocystinamide A." Organic Letters 2008, 10, 4449-4452.

Martinez-Luis, Sergio; Della-Togna, Gina; Coley, Phyllis D.; Kursar, Thomas A.; Gerwick, William H.; Cubilla-Rios, Luis. "Antileishmanial Constituents of the Panamanian Endophytic Fungus Edenia sp." J. Nat. Prod. 2008, 71, 2011-2014.

Linington, Roger G.; Edwards, Daniel J.; Shuman, Cynthia F.; McPhail, Kerry L.; Matainaho, Teatulohi; Gerwick, William H. "Symplocamide A, a Potent Cytotoxin and Chymotrypsin Inhibitor from the Marine Cyanobacterium Symploca sp." Journal of Natural Products (2008), 71(1), 22-27.


2007

Flatt, P. M.; O'Connell, S. J.; McPhail, K. L.; Zeller, G.; Willis, C. L.; Sherman, D., Gerwick, W. H.; "Characterization of the Initial Enzymatic Steps of Barbamide Biosynthesis" J. Nat. Prod. 2006, 69, 938-944.

Torres-Mendoza, Daniel; Gonzalez, Jose; Ortega-Barria, Eduardo; Heller, Maria V.; Capson, Todd L.; McPhail, Kerry; Gerwick, William H.; Cubilla-Rios, Luis. Weakly Antimalarial Flavonol Arabinofuranosides from Calycolpus warscewiczianus. Journal of Natural Products 2006, 69, 826-828.

Gross, H.; Goeger, D. E.; Hills, P.; Mooberry, S. L.; Ballantine, D. L.; Murray, T. F.; Valeriote, F. A.; Gerwick W. H. "Lophocladines, Bioactive Alkaloids from the Red Alga Lophocladia sp." J. Nat. Prod. 2006, 69, 640-644.

Simmons, T. L.; McPhail, K. L.; Ortega-Barria, E.; Gerwick, W. H. "Belamide A, a new cytotoxic tetrapeptide from a Panamanian marine cyanobacterium" Tetrahedron Lett. 2006, 47, 3387-3390.

Correa, Jhonny Edmith; Rios, Carlos Hernan; Castillo, Amparo del Rosario; Romero, Luz I.; Ortega-Barria, Eduardo; Coley, Phyllis D.; Kursar, Thomas A.; Heller, Maria Veronica; Gerwick, William H.; Rios, Luis Cubilla. Minor alkaloids from Guatteria dumetorum with antileishmanial activity. Planta Medica 2006, 72, 270-272.

Dorrestein, P. C.; Blackhall, J.; Straight, P. D.; Fischbach, M. A.; Garneau-Tsodikova, S.; Edwards, D. L.; McLaughlin, S.; Lin, M.; Gerwick, W. H.; Kolter, R.; Kolter, R.; Walsh, C. T.; Kelleher, N. L. Biochemistry 2006 45, 1537-1546.

Gu, Liangcai; Jia, Junyong; Liu, Haichuan; Hkansson, Kristina; Gerwick, William H.; Sherman, David H. Metabolic Coupling of Dehydration and Decarboxylation in the Curacin A Pathway: Functional Identification of a Mechanistically Diverse Enzyme Pair. Journal of the American Chemical Society 2006, 128, 9014-9015.

Gross, H.; Stockwell, V. O.; Henkels, M. D.; Nowak-Thompson, B.; Loper, J. E.; Gerwick, W. H. The Genomisotopic Approach: A Systematic Method to Isolate The Products Of Orphan Biosynthetic Gene Clusters, Chemistry and Biology 2007, 14, 53-63.

Suyama, T. L.; Gerwick, W. H. Practical Total Syntheses of Epiquinamide Enantiomers, Organic Letters, 2006, 8, 4541-4543.

Andersson, M. X.; Hamberg, M.; Kourtchenko, O.; Brunnström, A.; McPhail, K. L.; Gerwick, W. H.; Göbel, C.; Feussner, I.; Ellerström, M. Oxylipin profiling of the hyper sensitive response in Arabidopsis thaliana: Formation of a novel OPDA containing galactolipid, Arabidopside E, J. Biol. Chem., 2006, 281, 31528-31537.

Andrianasolo, E. H.; Goeger, D.; Gerwick, W.H. "Mitsoamide, a cytotoxic linear lipopeptide from the Madagascar marine cyanobacterium Geitlerinema sp." Pure & Applied Chemistry 2007, 79, 593-602.

Thomas A. Kursar, Catherina C. Caballero-George, Todd L. Capson, Luis Cubilla-Rios, William H. Gerwick, Mahabir P. Gupta, Alicia Ibañez, Roger G. Linington, Kerry L. McPhail, Eduardo Ortega-Barría, Luz I. Romero Pablo N. Solis and Phyllis D. Coley "1Obtaining Economic Benefits from Sustainable Use of Biological Diversity Through Bioprospecting" BioScience 2006, 56, 1005-1012.M


2006

Gross, Harald; Stockwell, Virginia O.; Henkels, Marcella D.; Nowak-Thompson, Brian; Loper, Joyce E.; Gerwick, William H.. The Genomisotopic Approach: A Systematic Method to Isolate Products of Orphan Biosynthetic Gene Clusters. Chemistry & Biology (2007), 14(1), 53-63.

Andersson, Mats X.; Hamberg, Mats; Kourtchenko, Olga; Brunnstroem, Aasa; McPhail, Kerry L.; Gerwick, William H.; Goebel, Cornelia; Feussner, Ivo; Ellerstroem, Mats. Oxylipin Profiling of the Hypersensitive Response in Arabidopsis thaliana. Formation of a Novel Oxo-Phytodienoic Acid-Containing Galactolipid, Arabidopside E. Journal of Biological Chemistry (2006), 281(42), 31528-31537.

Suyama, Takashi L.; Gerwick, William H. Practical Total Syntheses of Epiquinamide Enantiomers. Organic Letters (2006), 8(20), 4541-4543.

Gu, Liangcai; Jia, Junyong; Liu, Haichuan; Hkansson, Kristina; Gerwick, William H.; Sherman, David H. Metabolic Coupling of Dehydration and Decarboxylation in the Curacin A Pathway: Functional Identification of a Mechanistically Diverse Enzyme Pair. Journal of the American Chemical Society (2006), 128(28), 9014-9015.

Flatt, Patricia M.; O'Connell, Susan J.; McPhail, Kerry L.; Zeller, Gloria; Willis, Christine L.; Sherman, David H.; Gerwick, William H. Characterization of the Initial Enzymatic Steps of Barbamide Biosynthesis. Journal of Natural Products (2006), 69(6), 938-944.

Ramaswamy, Aishwarya V.; Flatt, Patricia M.; Edwards, Daniel J.; Simmons, T. Luke; Han, Bingnan; Gerwick, William H. The secondary metabolites and biosynthetic gene clusters of marine cyanobacteria. Applications in biotechnology. Frontiers in Marine Biotechnology (2006), 175-224.

Torres-Mendoza, Daniel; Gonzalez, Jose; Ortega-Barria, Eduardo; Heller, Maria V.; Capson, Todd L.; McPhail, Kerry; Gerwick, William H.; Cubilla-Rios, Luis. Weakly Antimalarial Flavonol Arabinofuranosides from Calycolpus warscewiczianus. Journal of Natural Products (2006), 69(5), 826-828.

Simmons, T. Luke; McPhail, Kerry L.; Ortega-Barria, Eduardo; Mooberry, Susan L.; Gerwick, William H.. Belamide A, a new antimitotic tetrapeptide from a Panamanian marine cyanobacterium. Tetrahedron Letters (2006), 47(20), 3387-3390.

Correa, Jhonny Edmith; Rios, Carlos Hernan; Castillo, Amparo del Rosario; Romero, Luz I.; Ortega-Barria, Eduardo; Coley, Phyllis D.; Kursar, Thomas A.; Heller, Maria Veronica; Gerwick, William H.; Rios, Luis Cubilla. Minor alkaloids from Guatteria dumetorum with antileishmanial activity. Planta Medica (2006), 72(3), 270-272.

Gross, Harald; Goeger, Douglas E.; Hills, Patrice; Mooberry, Susan L.; Ballantine, David L.; Murray, Thomas F.; Valeriote, Frederick A.; Gerwick, William H. Lophocladines, Bioactive Alkaloids from the Red Alga Lophocladia sp. Journal of Natural Products (2006), 69(4), 640-644.

Andrianasolo, Eric H.; France, Dennis; Cornell-Kennon, Susan; Gerwick, William H. DNA Methyl Transferase Inhibiting Halogenated Monoterpenes from the Madagascar Red Marine Alga Portieria hornemannii. Journal of Natural Products (2006), 69(4), 576-579.

Han, Bingnan; Gross, Harald; Goeger, Douglas E.; Mooberry, Susan L.; Gerwick, William H. Aurilides B and C, cancer cell toxins from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products (2006), 69(4), 572-575.

Dorrestein, Pieter C.; Blackhall, Jonathan; Straight, Paul D.; Fischbach, Michael A.; Garneau-Tsodikova, Sylvie; Edwards, Daniel J.; McLaughlin, Shaun; Lin, Myat; Gerwick, William H.; Kolter, Roberto; Walsh, Christopher T.; Kelleher, Neil L. Activity Screening of Carrier Domains within Nonribosomal Peptide Synthetases Using Complex Substrate Mixtures and Large Molecule Mass Spectrometry. Biochemistry (2006), 45(6), 1537-1546.


2005

LePage, Keith T.; Dickey, Robert W.; Gerwick, William H.; Jester, Edward L.; Murray, Thomas F. On the use of neuro-2a neuroblastoma cells versus intact neurons in primary culture for neurotoxicity studies. Critical Reviews in Neurobiology (2005), 17(1), 27-50.

Han, Bingnan; McPhail, Kerry L.; Gross, Harald; Goeger, Douglas E.; Mooberry, Susan L.; Gerwick, William H. Isolation and structure of five lyngbyabellin derivatives from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. Tetrahedron (2005), 61(49), 11723-11729.

LePage, K. T.; Goeger, D.; Yokokawa, F.; Asano, T.; Shioiri, T.; Gerwick, W. H.; Murray, T. F. The neurotoxic lipopeptide kalkitoxin interacts with voltage-sensitive sodium channels in cerebellar granule neurons. Toxicology Letters (2005), 158(2), 133-139.

Flatt, Patricia M.; Gautschi, Jeffrey T.; Thacker, Robert W.; Musafija-Girt, Mirjam; Crews, Phillip; Gerwick, William H. Identification of the cellular site of polychlorinated peptide biosynthesis in the marine sponge Dysidea (Lamellodysidea) herbacea and symbiotic cyanobacterium Oscillatoria spongeliae by CARD-FISH analysis. Marine Biology (Heidelberg, Germany) (2005), 147(3), 761-774.

Sabry, Omar M. M.; Andrews, Simeon; McPhail, Kerry L.; Goeger, Douglas E.; Yokochi, Alexandre; LePage, Keith T.; Murray, Thomas F.; Gerwick, William H.. Neurotoxic Meroditerpenoids from the Tropical Marine Brown Alga Stypopodium flabelliforme. Journal of Natural Products (2005), 68(7), 1022-1030.

Han, Bingnan; Goeger, Doug; Maier, Claudia S.; Gerwick, William H.. The wewakpeptins, cyclic depsipeptides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena. Journal of Organic Chemistry (2005), 70(8), 3133-3139.

Andrianasolo, Eric H.; Gross, Harald; Goeger, Douglas; Musafija-Girt, Mirjam; McPhail, Kerry; Leal, Rachel M.; Mooberry, Susan L.; Gerwick, William H.. Isolation of Swinholide A and Related Glycosylated Derivatives from Two Field Collections of Marine Cyanobacteria. Organic Letters (2005), 7(7), 1375-1378.

Simmons, T. Luke; Andrianasolo, Eric; McPhail, Kerry; Flatt, Patricia; Gerwick, William H.. Marine natural products as anticancer drugs. Molecular Cancer Therapeutics (2005), 4(2), 333-342.


2004-2002

Edwards, Daniel J.; Gerwick, William H.. Lyngbyatoxin Biosynthesis: Sequence of Biosynthetic Gene Cluster and Identification of a Novel Aromatic Prenyltransferase. Journal of the American Chemical Society (2004), 126(37), 11432-11433.

Chang, Zunxue; Sitachitta, Namthip; Rossi, James V.; Roberts, Mary Ann; Flatt, Patricia M.; Jia, Junyong; Sherman, David H.; Gerwick, William H.. Biosynthetic Pathway and Gene Cluster Analysis of Curacin A, an Antitubulin Natural Product from the Tropical Marine Cyanobacterium Lyngbya majuscula. Journal of Natural Products (2004), 67(8), 1356-1367.

Williamson, R. Thomas; Singh, Inder Pal; Gerwick, William H.. Taveuniamides: new chlorinated toxins from a mixed assemblage of marine cyanobacteria. Tetrahedron (2004), 60(33), 7025-7033.

Yokokawa, Fumiaki; Asano, Toshinobu; Okino, Tatsufumi; Gerwick, William H.; Shioiri, Takayuki. An expeditious total synthesis of kalkitoxins: determination of the absolute stereostructure of natural kalkitoxin. Tetrahedron (2004), 60(32), 6859-6880.

Edwards, Daniel J.; Marquez, Brian L.; Nogle, Lisa M.; McPhail, Kerry; Goeger, Douglas E.; Roberts, Mary Ann; Gerwick, William H.. Structure and Biosynthesis of the Jamaicamides, New Mixed Polyketide-Peptide Neurotoxins from the Marine Cyanobacterium Lyngbya majuscula. Chemistry & Biology (2004), 11(6), 817-833.

McPhail, Kerry L.; France, Dennis; Cornell-Kennon, Susan; Gerwick, William H.. Peyssonenynes A and B, novel enediyne oxylipins with DNA methyl transferase inhibitory activity from the red marine alga Peyssonnelia caulifera. Journal of Natural Products (2004), 67(6), 1010-1013.

Takamatsu, Satoshi; Nagle, Dale G.; Gerwick, William H.. Secondary metabolites from marine cyanobacteria and algae inhibit LFA-1/ICAM-1 mediated cell adhesion. Planta Medica (2004), 70(2), 127-131.

Li, W. I.; Marquez, B. L.; Okino, T.; Yokokawa, F.; Shioiri, T.; Gerwick, W. H.; Murray, T. F. Characterization of the Preferred Stereochemistry for the Neuropharmacologic Actions of Antillatoxin. Journal of Natural Products (2004), 67(4), 559-568.

Gafner, Stefan; Bergeron, Chantal; McCollom, Megan M.; Cooper, Lorena M.; McPhail, Kerry L.; Gerwick, William H.; Angerhofer, Cindy K. Evaluation of the Efficiency of Three Different Solvent Systems to Extract Triterpene Saponins from Roots of Panax quinquefolius Using High-Performance Liquid Chromatography. Journal of Agricultural and Food Chemistry (2004), 52(6), 1546-1550.

Crews, Phillip; Gerwick, William; Schmitz, Francis; France, Dennis; Bair, Kenneth; Wright, Amy; Hallock, Yali. Molecular Approaches to Discover Marine Natural Product Anticancer Leads - An Update from a Drug Discovery Group Collaboration. Pharmaceutical Biology (Lisse, Netherlands) (2003), 41(Suppl. 1), 39-52.

Han, Bingnan; McPhail, Kerry L.; Ligresti, Alessia; Di Marzo, Vincenzo; Gerwick, William H.. Semiplenamides A-G, fatty acid amides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena. Journal of Natural Products (2003), 66(10), 1364-1368.

Tan, Lik Tong; Sitachitta, Namthip; Gerwick, William H.. The guineamides, novel cyclic depsipeptides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products (2003), 66(6), 764-771.

Takamatsu, Satoshi; Hodges, Tyler W.; Rajbhandari, Ira; Gerwick, William H.; Hamann, Mark T.; Nagle, Dale G. Marine Natural Products as Novel Antioxidant Prototypes. Journal of Natural Products (2003), 66(5), 605-608.

Nogle, Lisa M.; Gerwick, William H.. Diverse secondary metabolites from a Puerto Rican collection of Lyngbya majuscula. Journal of Natural Products (2003), 66(2), 217-220.

Gerwick, William H.; Leslie, Pauline; Long, G. Cliona; Marquez, Brian L.; Willis, Christine L. [6-13C]-(2S,4S)-5-Chloroleucine: synthesis and incubation studies with cultures of the cyanobacterium, Lyngbya majuscula. Tetrahedron Letters (2002), Volume Date 2003, 44(2), 285-288.

Nogle, Lisa M.; Marquez, Brian L.; Gerwick, William H.. Wewakazole, a novel cyclic dodecapeptide from a Papua New Guinea Lyngbya majuscula. Organic Letters (2003), 5(1), 3-6.

McPhail, Kerry L.; Gerwick, William H.. Three new malyngamides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products (2003), 66(1), 132-135.

Stevenson, Christopher S.; Capper, Elizabeth A.; Roshak, Amy K.; Marquez, Brian; Eichman, Chris; Jackson, Jeffrey R.; Mattern, Michael; Gerwick, William H.; Jacobs, Robert S.; Marshall, Lisa A. The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore. Journal of Pharmacology and Experimental Therapeutics (2002), 303(2), 858-866.

Williamson, R. Thomas; Boulanger, Anna; Vulpanovici, Alexandra; Roberts, Mary A.; Gerwick, William H.. Structure and absolute stereochemistry of phormidolide, a new toxic metabolite from the marine cyanobacterium Phormidium sp. Journal of Organic Chemistry (2002), 67(23), 7927-7936.

Chang, Zunxue; Flatt, Patricia; Gerwick, William H.; Nguyen, Viet-Anh; Willis, Christine L.; Sherman, David H. The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit. Gene (2002), 296(1-2), 235-247.

Zheng, Wei; Wise, Mitchell L.; Wyrick, Annette; Metz, James G.; Yuan, Ling; Gerwick, William H.. Polyenoic fatty acid isomerase from the marine alga Ptilota filicina: protein characterization and functional expression of the cloned cDNA. Archives of Biochemistry and Biophysics (2002), 401(1), 11-20.

Marquez, Brian L.; Watts, Karl Shawn; Yokochi, Alexandre; Roberts, Mary Ann; Verdier-Pinard, Pascal; Jimenez, Jorge I.; Hamel, Ernest; Scheuer, Paul J.; Gerwick, William H.. Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly. Journal of Natural Products (2002), 65(6), 866-871.

Gerwick, William H.; Singh, Inder Pal. Structural diversity of marine oxylipins. Lipid Biotechnology (2002), 249-275.

Tan, Lik Tong; Marquez, Brian L.; Gerwick, William H.. Lyngbouilloside, a novel glycosidic macrolide from the marine cyanobacterium Lyngbya bouillonii. Journal of Natural Products (2002), 65(6), 925-928.

Gerwick, William. The Phytochemistry of the Macro and Blue-Green Algae of the Arabian Gulf. Journal of Natural Products (2002), 65(6), 950-951.

Stevenson, C. S.; Capper, E. A.; Roshak, A. K.; Marquez, B.; Grace, K.; Gerwick, W. H.; Jacobs, R. S.; Marshall, L. A. Scytonemin - a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases. Inflammation Research (2002), 51(2), 112-114.

Nogle, Lisa M.; Gerwick, William H.. Somocystinamide A, a novel cytotoxic disulfide dimer from a Fijian marine cyanobacterial mixed assemblage. Organic Letters (2002), 4(7), 1095-1098.

Nogle, Lisa M.; Gerwick, William H.. Isolation of four new cyclic depsipeptides, antanapeptins A-D, and dolastatin 16 from a Madagascan collection of Lyngbya majuscula. Journal of Natural Products (2002), 65(1), 21-24.

Yoo, Hye-Dong; Ketchum, Sharon O.; France, Dennis; Bair, Ken; Gerwick, William H.. Vidalenolone, a Novel Phenolic Metabolite from the Tropical Red Alga Vidalia sp. Journal of Natural Products (2002), 65(1), 51-53.




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